Article | Drug/Class | Study design | Sample size | Follow-up (months) | Withdrawal schedule |
Boulos 2019 | ACE-I, ARB, beta blockers, spironolactone, diuretics | Prospective cohort study | 277 | 6 | Not described |
Burr 1977 | Diuretics and potassium supplementation | RCT | 106 | 3 | Not described |
De Jonge 1994 | Diuretics | RCT | 63 | 1.5 | Not described |
McIntyre 2017 | Quinine, diuretics, alpha-1 blockers, PPIs, statins | Before-and-after study | 240 | 6 | Not described |
Myers 1982 | Diuretics | RCT | 77 | 12 | Not described |
Straand 1993 | Diuretics | Before-and-after study | 33 | 6 | Not described |
van Kraaij 2000 | Diuretics | RCT | 32 | 3 | Dose halved for 1 week, then substituted for placebo |
Walma 1993 | Diuretics | Before-and-after study | 15 | 6 | Thiazides and furosemide in daily dosages <40 mg were stopped abruptly Frusemide daily dosages >40 mg were halved for 1 week before withdrawal. |
Walma 1997 | Diuretics | RCT | 202 | 6 | Patients with 40mg frusemide daily halved the dose for one week. Patients with 80mg frusemide daily halved the dose for two weeks. Withdrawal schedule for other agents not described. |