Article | Drug/Class | Study design | Sample size | Follow-up (months) | Withdrawal schedule |
Browne 2016 | Beta-blockers | Non-randomised controlled trial | 29 | 3 | Tapered, other anti-hypertensive medications optimised |
Hearing 1999 | Atenolol | RCT | 37 | 0.5 (2 weeks) | Withdrawn over one week |
Jondeau 2009 | Beta-blockers | RCT – non inferiority | 169 | 3 | Abrupt discontinuation |
Yeh 2013 | Beta-blockers, antipsychotics, antidepressants, benzodiazepines | Prospective cohort study | 67 (3 on beta-blockers) | 3 | Slowly tapered off or switched to alternatives with lower anticholinergic burden according to research team recommendations |