Article | Drug/Class | Study design | Sample size | Follow-up (months) | Withdrawal schedule |
Alsop 2001 | Antihypertensives | Before-and-after | 65 | 30 | Not described |
Boulos 2019 | ACE-I, ARB, beta blockers, spironolactone, diuretics | Prospective cohort study | 277 | 6 | Not described |
Ekbom 1994 | Antihypertensives | Before-and-after study | 333 | 60 | Beta-blockers recommended to be reduced step-wise over a few days, to minimize sympathetic rebound. Other agents not described. |
Espeland 1999 | Antihypertensives | RCT – 3×2 factorial design | 975 | 60 | Not described |
Fotherby 1994 | Antihypertensives | Before-and-after study | 78 | 12 | Not described |
Franco Palacios 2015 | Antihypertensives and NSAIDs | Before-and-after study | 61 | 3 | Not described |
Gulla 2018 | Antihypertensives | Cluster RCT | 295 | 9 | Taper or abrupt discontinuation |
Hajjar 2013 | Antihypertensives | Before-and-after study | 53 | 0.75 (3 weeks) | Week 1: Dose reduced by 25%–50%. Week 2: Dose reduced by 50%–75%. Week 3: Cease |
Hansen 1983 | Antihypertensives | Before-and-after study | 168 | 12 | Not described |
Lernfelt 1990 | Antihypertensives | Historical cohort study | 25 | 48 | Not described |
Moonen 2015 | Antihypertensives | RCT | 385 | 4 | Tapered over six weeks until a maximum increase of 20mmHg in systolic blood pressure |
Moonen 2016 | Antihypertensives | RCT | 162 | 4 | Tapered over six weeks until a maximum increase of 20mmHg in systolic blood pressure |
Nadal 1994 | Antihypertensives | Before-and-after study | 86 | 36 | Not described |
Nelson 2002 | Antihypertensives | Case-control study | 503 | 12 | Step-wise withdrawal: 1 drug at a time, half doses at weekly intervals to the lowest usual therapeutic dose then cease |
Omer 2018 | Antihypertensives | Retrospective cohort study | 146 | Until hospital discharge | Not described |
Song 2018 | Antihypertensives | Retrospective cohort study | 2212 | 1 | Not described |
Willem van Dalen 2019 | Antihypertensives | Prospective cohort study | 1541 | 72 | Not described |